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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR : Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - Guangtao Zhang
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Guangtao Zhang:

Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR : Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - Pasta blanda

2011, ISBN: 3639309693

[EAN: 9783639309690], Nouveau livre, [SC: 10.99], [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Infectious diseases cause millions of deaths… Más…

NEW BOOK. Gastos de envío: EUR 10.99 AHA-BUCH GmbH, Einbeck, Germany [51283250] [Note: 5 (sur 5)]
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Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Guangtao Zhang
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Guangtao Zhang:

Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Pasta blanda

ISBN: 9783639309690

*Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR* - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival… Más…

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Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Guangtao Zhang
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Guangtao Zhang:
Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Pasta blanda

ISBN: 3639309693

Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR ab 58.99 € als Taschenbuch: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulat… Más…

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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and ?-Helix Mimetics as Modulators of Dormancy Survival Regulator - Pasta blanda

ISBN: 9783639309690

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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Pasta blanda

2011, ISBN: 9783639309690

Trade paperback, New., Trade paperback (US). Glued binding. 160 p., [PU: VDM Verlag]

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Detalles del libro
Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR
Autor:
Título:
ISBN:

9783639309690


Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 µM. It could serve as a promising drug to treat cholera. The second project is to use a-helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal.

Detalles del libro - Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR


EAN (ISBN-13): 9783639309690
ISBN (ISBN-10): 3639309693
Tapa dura
Tapa blanda
Año de publicación: 2011
Editorial: VDM Verlag Dr. Müller

Libro en la base de datos desde 2009-07-01T08:06:36-05:00 (Mexico City)
Página de detalles modificada por última vez el 2023-06-25T03:07:36-06:00 (Mexico City)
ISBN/EAN: 9783639309690

ISBN - escritura alterna:
3-639-30969-3, 978-3-639-30969-0
Mode alterno de escritura y términos de búsqueda relacionados:
Autor del libro: zhang
Título del libro: synthesis, helix

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