ISBN: 9781156574348

[ED: Taschenbuch], [PU: Books LLC, Reference Series], Source: Wikipedia. Pages: 54. Chapters: Apoptosis, Cytochrome c, P53, NF-B, Bcl-2, DNA damage theory of aging, Apoptosome, XIAP, ASK1… Más…

[ED: Taschenbuch], [PU: Books LLC, Reference Series], Source: Wikipedia. Pages: 54. Chapters: Apoptosis, Cytochrome c, P53, NF-B, Bcl-2, DNA damage theory of aging, Apoptosome, XIAP, ASK1, FADD, Bcl-2-associated death promoter, IKK2, Fas receptor, Fas ligand, Bcl-2-associated X protein, Autophagy, APAF1, Neurotrophin, CARD domain, Poly ADP ribose polymerase, BH3 interacting domain death agonist, Caspase, History and highlights in apoptosis research, Noxa, TrkC receptor, Perforin, PAC-1, Apoptosis-inducing factor, The Proteolysis Map, Paracaspase, 14-3-3 protein, Mitochondrial apoptosis-induced channel, Anoikis, Bleb, TUNEL assay, Autolysis, Granzyme, Necrobiology, Metacaspase, DNA laddering, Phenoptosis, P53 upregulated modulator of apoptosis, Pyknosis, Karyolysis, Autophagy database, Autoschizis, Pyroptosis, Suicide gene, Bcl-2 homologous antagonist killer, Karyorrhexis, Mitotic catastrophe, Death-inducing signaling complex, UVB-induced apoptosis. Excerpt: p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome", the "guardian angel gene", and the "master watchman", referring to its role in conserving stability by preventing genome mutation. The name p53 is in reference to its apparent molecular mass: It runs as a 53-kilodalton (kDa) protein on SDS-PAGE. But, based on calculations from its amino acid residues, p53's mass is actually only 43.7 kDa. This difference is due to the high number of proline residues in the protein, which slow its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish. p53 is also known as: In humans, p53 is encoded by the TP53 gene located on the short arm of chromosome 17 (17p13.1). The gene spans 20 kb, with a non-coding exon 1 and a very long first intron of 10 kb.The coding sequence contains five regions showing a high degree of conservation in vertebrates, predominantly in exons 2, 5, 6, 7 and 8, but the sequences found in invertebrates show only distant resemblance to mammalian TP53. TP53 orthologs have been identified in most mammals for which complete genome data are available. In humans, the two most common polymorphisms to occur involve the substitution of an arginine residue for a proline residue. This polymorphism arises out of a SNP mutation on the 72 codon, where a guanine base is replaced by a cytosine. For these mammals, the gene is located on different chromosomes: (Italics are used to denote the TP53 gene name and distinguish it from the protein it encodes.) Human p53 is 393 amino acids long and has seven domains: A tandem of nine-amino-acid transactivation domains (9aVersandfertig in 3-5 Tagen, [SC: 0.00]<

2010, ISBN: 9781156574348

[ED: Pappeinband], [PU: Bertrams Print On Demand], - Source: Wikipedia. Pages: 54. Chapters: Apoptosis, Cytochrome c, P53, NF-B, Bcl-2, DNA damage theory of aging, Apoptosome, XIAP, ASK1,… Más…

[ED: Pappeinband], [PU: Bertrams Print On Demand], - Source: Wikipedia. Pages: 54. Chapters: Apoptosis, Cytochrome c, P53, NF-B, Bcl-2, DNA damage theory of aging, Apoptosome, XIAP, ASK1, FADD, Bcl-2-associated death promoter, IKK2, Fas receptor, Fas ligand, Bcl-2-associated X protein, Autophagy, APAF1, Neurotrophin, CARD domain, Poly ADP ribose polymerase, BH3 interacting domain death agonist, Caspase, History and highlights in apoptosis research, Noxa, TrkC receptor, Perforin, PAC-1, Apoptosis-inducing factor, The Proteolysis Map, Paracaspase, 14-3-3 protein, Mitochondrial apoptosis-induced channel, Anoikis, Bleb, TUNEL assay, Autolysis, Granzyme, Necrobiology, Metacaspase, DNA laddering, Phenoptosis, P53 upregulated modulator of apoptosis, Pyknosis, Karyolysis, Autophagy database, Autoschizis, Pyroptosis, Suicide gene, Bcl-2 homologous antagonist killer, Karyorrhexis, Mitotic catastrophe, Death-inducing signaling complex, UVB-induced apoptosis. Excerpt: p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as the guardian of the genome, the guardian angel gene, and the master watchman, referring to its role in conserving stability by preventing genome mutation. The name p53 is in reference to its apparent molecular mass: It runs as a 53-kilodalton (kDa) protein on SDS-PAGE. But, based on calculations from its amino acid residues, p53's mass is actually only 43.7 kDa. This difference is due to the high number of proline residues in the protein, which slow its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish. p53 is also known as: In humans, p53 is encoded by the TP53 gene located on the short arm of chromosome 17 (17p13.1). The gene spans 20 kb, with a non-coding exon 1 and a very long first intron of 10 kb.The coding sequence contains five regions showing a high degree of conservation in vertebrates, predominantly in exons 2, 5, 6, 7 and 8, but the sequences found in invertebrates show only distant resemblance to mammalian TP53. TP53 orthologs have been identified in most mammals for which complete genome data are available. In humans, the two most common polymorphisms to occur involve the substitution of an arginine residue for a proline residue. This polymorphism arises out of a SNP mutation on the 72 codon, where a guanine base is replaced by a cytosine. For these mammals, the gene is located on different chromosomes: (Italics are used to denote the TP53 gene name and distinguish it from the protein it encodes.) Human p53 is 393 amino acids long and has seven domains: A tandem of nine-amino-acid transactivation domains (9a - Besorgungstitel - vorauss. Lieferzeit 3-5 Tage.., [SC: 0.00]<

2010, ISBN: 9781156574348

[ED: Pappeinband], [PU: Bertrams Print On Demand], - Source: Wikipedia. Pages: 54. Chapters: Apoptosis, Cytochrome c, P53, NF-B, Bcl-2, DNA damage theory of aging, Apoptosome, XIAP, ASK1,… Más…

[ED: Pappeinband], [PU: Bertrams Print On Demand], - Source: Wikipedia. Pages: 54. Chapters: Apoptosis, Cytochrome c, P53, NF-B, Bcl-2, DNA damage theory of aging, Apoptosome, XIAP, ASK1, FADD, Bcl-2-associated death promoter, IKK2, Fas receptor, Fas ligand, Bcl-2-associated X protein, Autophagy, APAF1, Neurotrophin, CARD domain, Poly ADP ribose polymerase, BH3 interacting domain death agonist, Caspase, History and highlights in apoptosis research, Noxa, TrkC receptor, Perforin, PAC-1, Apoptosis-inducing factor, The Proteolysis Map, Paracaspase, 14-3-3 protein, Mitochondrial apoptosis-induced channel, Anoikis, Bleb, TUNEL assay, Autolysis, Granzyme, Necrobiology, Metacaspase, DNA laddering, Phenoptosis, P53 upregulated modulator of apoptosis, Pyknosis, Karyolysis, Autophagy database, Autoschizis, Pyroptosis, Suicide gene, Bcl-2 homologous antagonist killer, Karyorrhexis, Mitotic catastrophe, Death-inducing signaling complex, UVB-induced apoptosis. Excerpt: p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as the guardian of the genome, the guardian angel gene, and the master watchman, referring to its role in conserving stability by preventing genome mutation. The name p53 is in reference to its apparent molecular mass: It runs as a 53-kilodalton (kDa) protein on SDS-PAGE. But, based on calculations from its amino acid residues, p53's mass is actually only 43.7 kDa. This difference is due to the high number of proline residues in the protein, which slow its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish. p53 is also known as: In humans, p53 is encoded by the TP53 gene located on the short arm of chromosome 17 (17p13.1). The gene spans 20 kb, with a non-coding exon 1 and a very long first intron of 10 kb.The coding sequence contains five regions showing a high degree of conservation in vertebrates, predominantly in exons 2, 5, 6, 7 and 8, but the sequences found in invertebrates show only distant resemblance to mammalian TP53. TP53 orthologs have been identified in most mammals for which complete genome data are available. In humans, the two most common polymorphisms to occur involve the substitution of an arginine residue for a proline residue. This polymorphism arises out of a SNP mutation on the 72 codon, where a guanine base is replaced by a cytosine. For these mammals, the gene is located on different chromosomes: (Italics are used to denote the TP53 gene name and distinguish it from the protein it encodes.) Human p53 is 393 amino acids long and has seven domains: A tandem of nine-amino-acid transactivation domains (9a - Besorgungstitel - vorauss. Lieferzeit 3-5 Tage.., [SC: 0.00]<

2011, ISBN: 115657434X

Kartoniert / Broschiert SCIENCE / Life Sciences / Cell Biology, mit Schutzumschlag neu, [PU:Books LLC, Reference Series]

2011, ISBN: 115657434X

Kartoniert / Broschiert SCIENCE / Life Sciences / Cell Biology, mit Schutzumschlag 11, [PU:Books LLC, Reference Series]