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Reactive Drug Metabolites - Amit S. Kalgutkar|Deepak Dalvie|R. Scott Obach|Dennis A. Smith
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Amit S. Kalgutkar|Deepak Dalvie|R. Scott Obach|Dennis A. Smith:

Reactive Drug Metabolites - encuadernado, tapa blanda

2012, ISBN: 3527330852

[EAN: 9783527330850], Neubuch, [PU: Wiley-VCH GmbH], CHEMIE MEDIZIN BASIC PHARMACOLOGY CHEMISTRY DRUG DISCOVERY & DEVELOPMENT GRUNDLAGEN DER PHARMAKOLOGIE MEDICAL SCIENCE TOXICOLOGY TOXIK… Más…

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Kalgutkar, Amit S.; Dalvie, Deepak; Obach, R. Scott; Smith, Douglas A.; Mannhold, Raimund [Series Editor]; Kubinyi, Hugo [Series Editor]; Folkers, Gerd [Series Editor];:

Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - encuadernado, tapa blanda

2012, ISBN: 9783527330850

Wiley-VCH, 2012-12-26. Hardcover. Used:Good., Wiley-VCH, 2012-12-26, 0

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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Douglas A. Smith, Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor):
Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - encuadernado, tapa blanda

2012

ISBN: 9783527330850

Wiley-VCH, 2012-12-26. 1. Hardcover. Good., Wiley-VCH, 2012-12-26, 2.5

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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers:
Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - encuadernado, tapa blanda

2012, ISBN: 3527330852

[EAN: 9783527330850], Neubuch, [PU: Wiley VCH 2012-10-24]

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Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith:
Reactive Drug Metabolites - Primera edición

2012, ISBN: 9783527330850

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Buch, Hardcover, 1. Auflage, [PU: Wiley-VCH], Wiley-VCH, 2012

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Datos bibliográficos del mejor libro coincidente

Detalles del libro
Reactive Drug Metabolites
Autor:
Título:
ISBN:

9783527330850


Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest
pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs.

The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive
and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating
the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented.

Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

Detalles del libro - Reactive Drug Metabolites


EAN (ISBN-13): 9783527330850
ISBN (ISBN-10): 3527330852
Tapa dura
Año de publicación: 2012
Editorial: Wiley-VCH
386 Páginas
Peso: 1,017 kg
Idioma: Englisch

Libro en la base de datos desde 2007-04-27T17:39:27-05:00 (Mexico City)
Página de detalles modificada por última vez el 2023-04-05T06:49:48-06:00 (Mexico City)
ISBN/EAN: 9783527330850

ISBN - escritura alterna:
3-527-33085-2, 978-3-527-33085-0
Mode alterno de escritura y términos de búsqueda relacionados:
Autor del libro: scott, deepak, amit, douglas smith, dennis, raimund, hugo kubinyi, gerd folkers, kalg
Título del libro: amit

Datos del la editorial

Autor: Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith
Título: Methods and Principles in Medicinal Chemistry; Reactive Drug Metabolites
Editorial: Wiley-VCH; Wiley-VCH
386 Páginas
Año de publicación: 2012-10-24
Impreso en
Peso: 1,000 kg
Idioma: Inglés
172,00 € (DE)
Not available (reason unspecified)
170mm x 240mm x 25mm

BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Chemie; Basic Pharmacology; Chemie; Chemistry; Drug Discovery & Development; Grundlagen der Pharmakologie; Medical Science; Medizin; Toxicology; Toxikologie; Wirkstoffforschung; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Toxikologie; Grundlagen der Pharmakologie

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

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