ISBN: 9783527655762

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide.… Más…

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.; PDF \ Victor Malyshkin; Scientific, Technical and Medical > Pre-clinical medicine: basic sciences > Physiology > Metabolism, Springer Berlin Heidelberg<

ISBN: 9783527655762

Wiley-VCH Pharmacology Reactive Drug Metabolites, drug metabolites, drug metabolite toxicity, toxicophores, IADRs, catalyzing reactive metabolite formation, drug-metabolizing, new drug ca… Más…

Wiley-VCH Pharmacology Reactive Drug Metabolites, drug metabolites, drug metabolite toxicity, toxicophores, IADRs, catalyzing reactive metabolite formation, drug-metabolizing, new drug candidates, structure-toxicity, toxicophore, toxicological potential, top 200 prescription drugs, toxicity, toxicity risk, metabolite-prone, toxicology, medicinal chemists, pfizer, drug development, drug metabolism,, pharmacology, Amit Kalgutkar, Deepak Dalvie, Scott Obach, new drugs, reactive metabolites, Mutagenesis, Carcinogenesis, Hepatotoxicants, cytotoxicity, intoxication, detoxification, parent drug, reversible pharmacology, genotoxicity, Carcinogenicity, Heteroaromatic Amines , Drug-Metabolizing Enzymes , Bioactivation and Inactivation of Cytochrome P450 , drug-drug interactions, pharmacokinetic, mechanism-based inactivation, Quinones, Quinone Imines, Quinone Methides, Cytochrome P450 Inactivators , Acetaminophen, Halothane, Hydralazine, Tienilic Acid, Toxicophores, Intrinsically Electrophilic Compounds as a Liability in Drug Discovery, pharmacological, nonenzymatically, Eliminating Reactive Metabolite Formation in Drug Discovery , /Reducing Reactive Metabolite Formation in Drug Discovery, Mitigating Toxicity Risks, Affinity Labeling Drug Candidates, Reactive Metabolite–Positive Compounds, Managing IADRs , 9783527330850, UK,GB,DE,ES,FR,IT,US,CA,MX,AU,NZ 20120906 English Medicine 1, Wiley<

ISBN: 9783527655762

Reactive Drug Metabolites: Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith Reactive Drug Metabolites: Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith e… Más…

Reactive Drug Metabolites: Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith Reactive Drug Metabolites: Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith eBooks > Belletristik > Erzählungen, Wiley-VCH<

2012, ISBN: 9783527655762

eBooks, eBook Download (EPUB), Auflage, [PU: Wiley-VCH], [ED: 1], Wiley-VCH, 2012

2012, ISBN: 9783527655762

[ED: 1], 1. Auflage, eBook Download (EPUB), eBooks, [PU: Wiley-VCH]